Here is my code for file handler, i hope it help to all:

First a class to handler file upload:
<?php
    define('UPLOAD_PATH', 'upload/');
    define('MAXIMUM_FILESIZE', '10485760'); //10 MB
    class FileHandler
    {
        private $file_types = array('xls', 'xlsx');
        private $files = null;
        private $filename_sanitized = null;
        private $filename_original = null;
        
        
        public function __construct($files)
        {
            $this->files = $files;    
        }
        
        public function setFileTypes($fileTypes = array())
        {
            $this->file_types = $fileTypes;
            return $this;
        }
        
        public function setFileNameOriginal($filename)
        {
            $this->filename_original = $filename;
        }
        
        public function fileNameOriginal()
        {
            return $this->filename_original;
        }
        
        public function sanitize($cursor = 0)
        {
            $this->setFileNameOriginal($this->files['name'][$cursor]);
            
            $safe_filename = preg_replace(
                    array("/\s+/", "/[^-\.\w]+/"),
                    array("_", ""),
                    trim($this->fileNameOriginal()));
            $this->filename_sanitized  = md5($safe_filename.time()).$safe_filename;
            return $this;
        }
        
        public function fileSize($cursor = 0)
        {
            return $this->files['size'][$cursor];
        }
        
        public function extensionValid()
        {
            $fileTypes = implode('|', $this->file_types);
            $rEFileTypes = "/^\.($fileTypes){1}$/i";
            if(!preg_match($rEFileTypes, strrchr($this->filename_sanitized, '.')))
                throw new Exception('No se pudo encontrar el tipo de archivo apropiado');
            
            return $this;
        }
        
        public function isUploadedFile($cursor)
        {
            if(!is_uploaded_file($this->files['tmp_name'][$cursor]))
            {
                throw new Exception("No se obtuvo la carga del archivo");
            }
        }
        
        public function saveUploadedFile($cursor)
        {
            if(!move_uploaded_file ($this->files['tmp_name'][$cursor],UPLOAD_PATH.$this->filename_sanitized))
                throw new Exception("No se consigui&oacute; guardar el archivo");
        }
        
        public function fileNameSanitized()
        {
            return $this->filename_sanitized;
        }
        
        public function uploadFile($cursor = 0)
        {
            $this->isUploadedFile($cursor);
            if ($this->sanitize($cursor)->fileSize($cursor) <= MAXIMUM_FILESIZE)
            {
                $this->extensionValid()->saveUploadedFile($cursor);
            }
            else 
            {
                throw new Exception("El archivo es demasiado grande.");
            }
            return $name;            
        }
        
    }

?>

Next a part of code to use the class

<?php
//form is submited  and detect that
if ($form_submited == 1)
{
    try
    {
                //i assume de input file is:
                /*
                       <input id="<?php echo EXCEL_FILE;?>[]" name="<?php echo EXCEL_FILE;?>[]" type="file"/>
                       where EXCEL_FILE is the constant: 
                       define('EXCEL_FILE', 'excel_file');
                */
        $file = new FileHandler($_FILES['excel_file']);
        $inputFileName = $file->uploadFile()->fileNameSanitized();  // File to read
                ...
        
    }
    catch(Exception $e)
    {
        die('Error cargando archivo "'.($file->fileNameOriginal()).'": '.$e->getMessage());
    }
    
    
}
?>